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KMID : 0381120180400050465
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Genes and Genomics
2018 Volume.40 No. 5 p.465 ~ p.473
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Analyses of karyotype by G-banding and high-resolution microarrays in a gender dysphoria population
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Fernandez Rosa
Guillamon Antonio
Gomez-Gil Esther
Esteva Isabel
Almaraz Mari Cruz
Cortes-Cortes Joselyn
Lamas Beatriz
Lema Estefania
Pasaro Eduardo
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Abstract
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Gender Dysphoria is characterized by a marked incongruence between the cerebral sex and biological sex. To investigate the possible influence of karyotype on the etiology of Gender Dysphoria we carried out the cytogenetic analysis of karyotypes in 444 male-to-females (MtFs) and 273 female-to-males (FtMs) that attended the Gender Identity Units of Barcelona and Malaga (Spain) between 2000 and 2016. The karyotypes from 23 subjects (18 MtFs and 5 FtMs) were also analysed by Affymetrix CytoScan™ high-density (HD) arrays. Our data showed a higher incidence of cytogenetic alterations in Gender Dysphoria (2.65%) than in the general population (0.53%) (p?
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KEYWORD
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17q21.31 microduplication, Aneuploidy, Gender Dysphoria, KANSL1, Klinefelter syndrome
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